Retinol, or all-trans-retinol, was the first vitamin to be synthesized in a laboratory (they are derived from vitamin A). It caught the attention of cosmetic chemists in early 1960, but it wasn't until 1990 that this molecule could be used as a component for skincare products. Not only retinol was commercialized for topical application, but they're also derivates referred to as retinoids. They have been used especially for acne, psoriasis, rosacea, and especially as anti-aging agents.