1.Acclimatize in Cusco: With Cusco perched at a lofty height (around 11,000 feet), spending at least 2-3 nights acclimating before your hike is crucial. This allows your body to adjust to the thinner air, significantly reducing the risk of altitude sickness. Symptoms like headaches, nausea, fatigue, and shortness of breath are common. Take it slow, avoid strenuous activity initially, and prioritize staying hydrated.