The gameplay of Mutant Last Stand is a third-person action wave game. From a behind-the-back camera angle, you control the mutant with mouse and keyboard. WASD for movement, spacebar to jump, and moving the mouse to move camera. With using LMB and RMB, you can do a melee attack to attack enemies, who will go down on one hit. The enemies will try to move, aim, and fire to take your Health down to Zero. The waves are endless so the goal is try and stay alive for as long as possible.