Adeel Khan

This longitudinal study evaluates the impact of a specific intervention on cardiac development and function in a pediatric cohort from age 1 to age 5. By utilizing linear mixed-effects models, the project tracks the trajectories of systolic performance and structural remodeling, specifically measuring Ejection Fraction, Left Ventricular Mass, and Wall Thickness. The primary objective is to determine if the treatment alters the natural growth patterns of the heart compared to a standard control group.

The results demonstrate that while both groups undergo age-related physiological changes, the treated group exhibits significantly accelerated improvements in heart function and more pronounced structural changes. By accounting for individual variability through random effects, the project provides robust evidence that the intervention drives a unique remodeling process characterized by enhanced pumping efficiency and distinct morphological adaptation.