APPON, was established by a group of Pharmaceutical entrepreneurs with the view to facilitate, enhance and improve the service of the Pharmaceutical companies to co-ordinate with different government bodies, medical fraternity and pharmaceutical business houses. Today, it has 50 Pharmaceutical companies as its members, who govern the 45% of Nepalese Pharmaceutical market share, out of which approximately 50% of which are certified with WHO-GMP and others are in process of it.