I started having bad effects right away after taking the suggested dose, like feeling sick and having headaches that wouldn't go away for over 12 hours. After taking it easy for a day, I slowly ate one gummy and felt the same affects right away. After a break of two days, the routine resumed. I feel bad that I couldn't return the two bottles that weren't opened. Unfortunately, I didn't expect such bad replies, which cost me $60. Before committing to big purchases, it's best to buy a single bottle first to see how different people react. I'm sorry to say that this product did not meet my wants. Allen J.