Yes, it's possible! Oh, okay, I'm a bit of a liar :)
Let's call it faux 3D animation :) And yes, it is possible!
Here's one of my many projects for the educational company iDoRecall.
Using the amazing sketches of the human brain in different angles created by Lev A. Mazin, Sketch and Rive I created a false 3D animation of the brain turning.
In addition, together with David Handel and Lev A. Mazin we told a story about how the iDoRecall app helps people learn more effectively and memorize information more easily.