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Shifa Regenerative & Rejuvenation Clinic is a regenerative medicine clinic which specializes in stem cell therapy and PRP procedures for multiple different illnesses including chronic pain and chronic illnesses. Our expert doctors are highly committed to treat and help manage a patient’s condition, ensuring that they provide the best-fit treatment. Stem cell therapy uses the body’s ability to heal and regenerate damaged or injured cells using adult stem cell and platelet solutions. These solutions help with common injuries as well as a variety of medical conditions.

Regenerative medicine is a game-changing area of medicine with the potential to fully heal damaged tissues and organs, offering hope for people who have conditions that are told to be beyond repair with conservative treatments. Specialized doctors at the Shifa Regenerative and Rejuvenation Clinic are experts in multiple areas of medicine including rheumatology, endocrinology, neuropathy, orthopedic, podiatry, pulmonary/respiratory and urology.

Shifa Regeneration and Rejuvenation clinic is a state-of-the-art freestanding multi-specialty surgery center that is equipped and staffed with the best of the best. It is certified by the department of health services, Medicare, AAAHC, and AAAASF.

At Shifa Regeneration and Rejuvenation clinic, our patient is our utmost priority. With excellent equipment and top of the line customer service, we strive to provide comfort and health to our patients.

Stem cells are the body’s raw materials — cells from which all other cells with specialized functions are generated. Under the right conditions in the body or a laboratory, stem cells divide to form more cells called daughter cells.

These daughter cells either become new stem cells (self-renewal) or become specialized cells (differentiation) with a more specific function, such as blood cells, brain cells, heart muscle or bone. No other cell in the body has the natural ability to generate new cell types.

Stem cells are the foundation of development in plants, animals and humans. In humans, there are many different types of stem cells that come from different places in the body or are formed at different times in our lives. These include embryonic stem cells that exist only at the earliest stages of development and various types of tissue-specific (or adult) stem cells that appear during fetal development and remain in our bodies throughout life.

Stem cells are defined by two characteristics:

-They can make copies of themselves, or self-renew

-They can differentiate, or develop, into more specialized cells

Beyond these two things, though, different types of stem cells differ a great deal in their behaviors and capabilities.

1.UMBILICAL CORD STEM CELL

The umbilical cord contains certain cells that can be found in bone marrow and help generate red blood cells and immune system cells. Umbilical Cord Stem Cell Injections have shown excellent results against many diseases including disc disease, joint arthritis, ligament injuries, spinal arthritis, and tendonitis.

2.PLATELET RICH PLASMA

Plasma is a component of your blood that contains proteins and special factors that help clotting. Platelet Rich Plasma or PRP is a substance that helps promote healing when injected hence has shown great results when used for injuries or degenerative diseases. Shifa Rejuvenation is the only institute in Pakistan that provides PRP injections. These injections are verified by Drug Regulatory Authority Pakistan (DRAP) to provide quality treatment to patients.

3.AMNIOTIC DERIVED STEM CELLS

Amniotic stem cells are those cells that are obtained from the amniotic fluid as well as the membrane. These types of cells can develop into various tissues including cartilage, cardiac tissue, muscle, nerves, bone and skin which is why it is a highly effective treatment for many diseases. Shifa Rejuvenation is the only institute in Pakistan that is providing and working with amniotic and umbilical materials. We only supply Amniotic Derived Stem Cells after getting them approved from the FDA to ensure quality treatment.

Human body is made up of cells and aging occurs when there is cell death. As an infant, child and young adult, our body’s cells are strong, resilient and can make new cells. As the years advance body’s ability to generate new cells diminishes these cells die and the aging process occurs. You can tell your skin is aging by the following symptoms:

-Sagging skin

-Wrinkles

-Inelasticity

-Dark circles

-Dullness

Arthritis is a condition that causes tenderness, pain and swelling in joints. It creates discomfort to its host patient along with weakening of joints and bones. The condition is so common that almost 54 million Americans have been diagnosed by doctors and around 300000 babies and kids have arthritis. Doctors- diagnosed arthritis prevails more in women than men. The main symptoms of arthritis are joint pain and stiffness, which typically worsen with age. The most common types of arthritis are osteoarthritis and rheumatoid arthritis. Most common symptoms of arthritis are:

-Pain and stiffness in the affected joint

-Swelling and tenderness around the area

-Bone spurs can also develop around the joint.

Osteoarthritis is by far, the most common type of arthritis and affects millions of people worldwide.it is commonly known as wear and tear disease People suffering from obesity, metabolic diseases like diabetes or those born with bone or cartilage deformities are at a greater risk of developing arthritis. Osteoarthritis is characterized by a slow and gradual deterioration in health.

Human immune system normally guards against germs like bacteria and viruses. When it senses any foreign invaders, it sends out an army of fighter cells to attack them. The immune system normally can tell the difference between foreign cells and your own cells. In an autoimmune disease, the immune system mistakes part of human body like joints or skin as foreign. It releases proteins called autoantibodies that attack healthy cells. Although symptoms of autoimmune differ according to the type of condition but some common symptoms include:

-Fatigue

-Digestive issues

-Swollen glands

-Poor metabolism

Immune system disorders cause abnormally low activity or over activity of the immune system. In cases of immune system over activity, the body attacks and damages its own tissues (autoimmune diseases). Not many causes are known for this disease but several researches suggest that genetics, infections and tissue damages maybe the cause of autoimmune disease. Women are at higher risk of developing autoimmune disorder because of excessive hormones level during child bearing phase, according to a theory. Common autoimmune diseases are Type 1 diabetes, Rheumatoid arthritis, multiple sclerosis and grave’s disease

Cartilage is an important part of the human body. It is a connecting tissue that is found particularly between the joints. It is a hard tissue but it is much softer and flexible than the average human bone. Examples include knees, elbows, ankles, ears, and nose. Cartilage defects are more commonly observed in the knees and are often the result of serious injuries or due to ligament tear. Though the cartilage deteriorates with age factor, the defect’s occurrence is seen in people as young as 20 to 30 years. Symptoms of the cartilage defect are

-Sore joints

-Extreme stiffness or swelling

-Inflamed joints

-Clicking or grinding sensation in joints

Cartilage is an important structural part of human body. It is a firm tissue but is quite softer and flexible than the bone. Cartilage defects occur due to several reasons like age, pregnancy, obesity, diabetes and birth abnormalities just to name a few.

Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory lung disease that causes obstructed airflow from the lungs. Symptoms include breathing difficulty, cough, mucus production and wheezing. It is caused by long-term exposure to irritating gases or particulate matter, most often from cigarette smoke. People with COPD are at increased risk of developing heart disease, lung cancer and a variety of other conditions.COPD is an umbrella term used to describe progressive lung diseases including emphysema, chronic bronchitis, and refractory (non-reversible) asthma. Common symptoms include:

-Breathlessness

-Wheezing

-Chest tightness

-Frequent respiratory infections

-Chronic cough that may produce mucus

This disease is characterized by increasing breathlessness. Most cases of COPD are caused by inhaling pollutants that includes tobacco smoking (cigarettes, pipes, cigars, etc.), and second-hand smoke. Fumes, chemicals and dust found in many work environments are contributing factors for many individuals who develop COPD. Genetics also play a role in development of COPD even if the person has never smoked or has ever been exposed to strong lung irritants in the workplace.

Diabetes is a disease in which blood glucose or blood sugar levels are too high. Glucose comes from the foods you eat. Insulin is a hormone that uses sugar (glucose) from carbohydrates in the food for energy or to store glucose for future use. Insulin helps keeps your blood sugar level from getting too high (hyperglycemia) or too low (hypoglycemia). In type 1 diabetes, your body does not make insulin. With type 2 diabetes, the more common type, your body does not make or use insulin well. Without enough insulin, the glucose stays in your blood. You can also have pre diabetes. This means that your blood sugar is higher than normal but not high enough to be called diabetes. Common symptoms displayed in patients with diabetes are:

-Increased thirst and urination

-Increased hunger

-Fatigue

-Blurred vision

-Numbness or tingling in the feet or hands

-Sores that do not heal

-Unexplained weight loss

Type 1 diabetes occurs when the body’s immune system attacks and destroys the insulin producing beta cells of the pancreas. Scientists think type 1 diabetes is caused by genes and environmental factors, such as viruses, that might trigger the disease. Type 2 diabetes is the most common form of diabetes is caused by several factors, including lifestyle factors and genes. Obesity, physical inactivity, insulin resistance are the triggering elements of diabetes type 2.

Erectile dysfunction (ED) is defined as persistent difficulty achieving and maintaining an erection sufficient to have sex. Causes are usually medical but can also be psychological. Problems getting or keeping an erection can also be a sign of an underlying health condition that needs treatment and a risk factor for heart disease. Common symptoms of this condition are:

-Trouble getting an erection.

-Trouble keeping an erection.

-Reduced sexual desire.

Sometimes a combination of physical and psychological issues causes erectile dysfunction. For instance, a minor physical condition that slows your sexual response might cause anxiety about maintaining an erection. The resulting anxiety can lead to or worsen erectile dysfunction. Physical causes include sleep disorder, heart disease, clogged blood vessels (atherosclerosis), high cholesterol, diabetes, obesity and metabolic syndrome.

8.Kidney Failure

Kidney failure is the inability of the kidneys to carry out their normal functions – functions including filtering waste products from the blood, regulating blood pressure, maintaining electrolyte balance, and production of red blood cells – due to damage. Kidney failure is also referred to as end-stage kidney/renal disease which specifies that the kidneys are functioning at less than 15% of normal.

There are two types of kidney failure: acute renal failure or acute kidney injury and chronic renal failure.

Acute renal failure results when the kidneys suddenly stop working, usually within two days. The kidneys are said to be injured in acute renal failure as kidney function is rapidly lost. However, normal or almost normal functioning may be recovered with treatment and the patient has no other serious health issues. Chronic kidney failure, the final stage of chronic kidney disease, develops slowly, usually over months and years. Unlike acute renal failure, it is irreversible and the only remedy would be to carry out dialysis or kidney transplant surgery.

Almost no symptoms are observed in the early stages of chronic renal failure, until when one is nearing the last stage of the condition. The symptoms observed during this stage are usually due to the accumulation of wastes in the blood and the body, a condition called azotemia. Symptoms, if any at all, produced for very low levels of azotemia, are usually few. But as the condition progresses, and the levels of azotemia rise, symptoms begin to become noticeable. The following are symptoms of kidney failure classified based on the accumulation of a certain type of waste product:

Based on accumulation of high levels of urea:

-Vomiting or diarrhea, or both

-Nausea

-Weight loss

-Blood in the urine

-Nocturnal urination

-More frequent urination, or in greater amounts than usual, with pale urine

-Less frequent urination, or in smaller amounts than usual, with dark colored urine

-Pressure, or difficulty urinating

Based on accumulation of excess phosphates (hyperphosphatemia):

-Itching

-Muscle cramps

-Bone damage

Based on accumulation of excess potassium (hyperkalemia):

-Muscle paralysis

-Abnormal heart rhythms

Based on accumulation of excess fluid:

-Generalized swelling (edema)

-Shortness of breath

Other symptoms may include:

-Tiredness

-Memory problems

-Difficulty focusing

-Dizziness

-Low blood pressure

-Foamy or bubbly urine

-Loss of appetite, which may include a bad taste in the mouth

-Darkening of skin

-Difficulty sleeping

-Excess protein in the blood

-High doses of penicillin may cause seizures in people with kidney failure

Common causes of acute kidney injury include inadequate blood flow to the kidneys, a heart attack, drug abuse and urinary tract problems whereas the most common cause of chronic kidney failure is diabetes, followed by high blood pressure. Other less common causes include: nephrotic syndrome, autoimmune diseases like lupus, polycystic kidney disease and urinary tract problems.

Neck pain is also known as cervicalgia, and it is pain localized around the neck region. Even though the pain is felt at the neck, it can be caused by several conditions in other parts of the body, including spinal problems. Neck pain can be caused by tightness of the muscles around the neck and upper back. Some muscles, like the trapezium, extend from the back and shoulder to the upper neck, and tension in its fibers can lead to neck pain. It may also arise due to nerve related uses. In this case, the nerves involved arise from the cervical part of the spinal cord and pass through the foramina in the cervical vertebrae (the bones of the spine). When neck pain is caused by these nerves, there is usually a pinched nerve, either due to the compartmental syndrome, muscle tightness, spinal arthritis, or a series of other conditions. The major symptom of neck pain is pain localized in the neck region. The pain may also spread to the surrounding areas like the base of the skull and the shoulders. The symptoms are usually worsened by activity like turning and stretching the neck and are relieved by rest. Depending on the cause of neck pain, it may also have accompanying symptoms like

-Headache

-Fatigue

-Neck stiffness

-Loss of range of motion

Neck pain can be caused by several factors including pain from the bones which can most likely be arthritis. It can also be due to a strain or a muscle pull as well as can arise due to nerve compression. Migraines can also cause neck pain. Neck pain can also come on as referred pain which is when there is an injury to an internal organ due to which pain is radiating throughout different areas of the body. Stress, injuries and whiplash can also cause neck pain.

Rheumatoid arthritis is a chronic condition characterized by an inflammation of the joints, especially those of the hands and feet. It is an autoimmune disease, which means that it is caused by the body’s immune system. In this condition, the immune system attacks the tissues of the body, focusing on the joint linings. This then leads to swelling, warmth and pain around the joints. Rheumatoid arthritis is known to manifest in different ways, and these often differ from person to person. Additionally, the duration of the symptoms differ. Some individuals can feel them for months at a time while others can go long periods without any bouts of pain or discomfort. Rheumatoid arthritis can cause the following symptoms:

-It affects the same joint on each sides of the body

-Morning stiffness

-Deformity: When left unattended for long periods, or in very severe cases, rheumatoid arthritis can cause deformation of the joins affected.

There are also symptoms that are not exclusive to rheumatoid arthritis but are experienced by individuals who suffer from the condition. They include:

-Redness and warmth

-Body aches\muscle aches

-Loss of appetite

-Fatigue

-Fever

-Nausea

-Depression

These symptoms are worse in people who have low activity levels. Generally, the more active an individual, the less the symptoms of the disease will be.

As rheumatoid arthritis is an autoimmune disease, it is still not known what causes this. Genetics do play a role but there is still little research on the causes of this condition.

Sciatica is a medical term that refers to pain in the back and legs caused by injury of the sciatic nerve. The term sciatica is often used interchangeably with another medical condition—radiculopathy. Radiculopathy refers to pain that travels along the course of a nerve, from the lumber plexus to the leg. Sciatica is often triggered by injury or compression to the sciatic nerve and can cause discomfort. Sciatica is like several other conditions that cause low back pain, which makes it very difficult to tell the condition apart from the rest. However, unlike the other conditions mentioned above, sciatica causes a specific kind of low back pain. In this condition, the pain extends from the hip, down to the buttocks and thighs, and even to the legs. Another unique thing about sciatica is that the pain usually affects one side of the leg. This is different from causes like arthritis that affect both sides of the body. Some other symptoms associated with sciatica are:

-The pain is usually worse when the individual sits

-Coughing or sneezing may aggravate the pain

-Impaired sensation like numbness, tingly sensations

-Weakness. This weakness usually affects the muscles supplied by the sciatic nerve, and that is another way that the condition is diagnosed.

The way sciatica manifests differ from person to person, and some people experience severe and debilitating pain. This often makes them unable to function normally. In some others, the pain may come very seldom, and with mild severity. There are also extreme cases, in which sciatica can lead to loss of bowel and bladder control and even complete loss of sensation in the upper thighs.

Sciatica is caused by injury or pressure to the sciatic nerve. This injury usually occurs at the low back, particularly close to the nerve’s origin. This injury could be in the form of irritation at the nerve root(s). Since the nerve originates from both the lumbar and sacral spine, any irritation in these areas can cause sciatica. Other causes of this condition include:

-Spinal stenosis. Spinal stenosis is also known as narrowing of the spinal canal.

-Osteoarthritis

-Degenerative disc disease. In this condition, the disc between two vertebrae degenerates, which then reduces the space between them. As a result, they begin to pinch on the nerve.

-Spondylolisthesis (forward or backward shift of one vertebrae bone on another)

-Pregnancy. Pressure placed on the sciatic nerve by the uterus and baby during pregnancy can also compress the sciatic nerve and lead to sciatica

-Muscle spasms. Involuntary contractions of the muscles in the back or buttocks.

-Obesity

-Sedentary lifestyle

-High heels have also been identified as an indirect cause of sciatica.

-Spinal tumors. Tumors that grow on the spinal cord can

-Piriformis syndrome

A stroke occurs when there is an interruption or reduction of blood supply to the brain which cause the brain tissue to be deprived of oxygen and nutrients. Due to this, brain cells begin to die. This is a medical emergency and prompt treatment is crucial with early action minimizing brain damage and complications. The symptoms of a stroke include:

-Trouble speaking and understanding. You may experience confusion, slur your words or find it difficult to understand what is being said.

-Paralysis or numbness in the face and limbs. Sudden weakness, numbness or paralysis in your face, arm or leg can be a warning side. These symptoms often only affect one side of your body.

-Trouble with seeing in one or both eyes. You may experience sudden blurred or blackened vision in one or either eyes, or you may see double.

-Headache. A sudden, severe headache, which may be accompanied by vomiting, dizziness or altered consciousness, may indicate you're having a stroke.

-Trouble with walking and balance. You may stumble or experience sudden dizziness, loss of balance or loss of coordination.

There are multiple different types of strokes but most of them occur due to blood clots in the arteries that supply blood to the brain or hemorrhage. Causes of these usually include hypertension, blood thinners, high cholesterol or aneurysms which are weak spots in your blood vessel walls.

Platelet-rich plasma therapy is a procedure that treats various conditions including tendonitis, arthritis, chronic joint inflammation, cartilage defects, and muscle strains. It also is used for skin and hair. Platelet-rich plasma therapy uses the patients’ own blood cells to control pain and increase functionality through regeneration of cells that help repair damaged or injured tissue.

The procedure of PRP starts with blood being drawn from the patient and then separated into three layers – the serum, platelets and white blood cells, and red blood cells. The platelets release over 1,000 biologically active proteins that facilitate tissue regeneration. Several studies have shown that PRP is very effective for degenerative diseases especially knee arthritis. One study showed that a platelet serum injected into a damaged Achilles tendon in a laboratory animal significantly increased tendon strength and stiffness as well as increased tendon strength and fast-twitch responses.

In the United States, PRP is being used by many people including athletes to help with their injuries as well as degenerative diseases. It is an effective treatment and has worked wonders for people who have used it.

Umbilical cord tissue cell therapy is one of the most cutting edge regenerative procedures available in the world. Shifa Rejuvenation works with Umbilical Cord Tissue to help regenerate and rejuvenate injured or degenerated tissue.

The umbilical cord tissue is obtained ethically from donors after a scheduled C-section, where the baby and mother are perfectly healthy. There are no embryonic stem cells used in the procedures at all. The umbilical cord tissue is processed along with Wharton’s Jelly and amniotic fluid at an FDA certified facility and then used for stem cell therapy procedures. To date, no known significant adverse events have occurred with umbilical cord tissue therapy.

The umbilical cord cell therapies include growth factors, exosomes, cytokines, microRNA and stem cells. Procedures are all out-patient and frequently help patients achieve an increased quality of life. While outcomes vary between individuals, patients often are able to walk farther, participate in recreational activities, breathe easier, sleep better and experience increased energy after their stem cell therapy procedure.

Stem cell therapy procedures using fat and bone marrow derived cells are outpatient procedures that involve harvesting the patient’s own tissue with immediate processing to concentrate stem cells and growth factors. The patient’s tissue is then injected during the same setting into the affected area. Fat Derived Stem Cell procedures take between two and three hours to harvest and process the tissue. Bone Marrow stem cell procedures take about 30 minutes.

Fat Derived Stem Cell and Bone Marrow Stem Cell procedures are the lowest in risk as the patient’s own stem cells are used. They have proven to be effective in treating and managing multiple chronic illnesses including arthritis and diabetes.

Research is currently underway on exosome therapy and as time passes, it is becoming increasingly popular as a treatment option for chronic illnesses. Interestingly, exosomes are cellular byproducts known as extracellular vesicles and are not actually cells.

When a stem cell releases an exosome, it contains significant information from that cell such as DNA and microRNA. Upon colliding with the damaged or injured cell, the exosome transfers all the information from it to the other cell. The reaction from that information transferred, depending on the cell, may be a repair response or a “reprogramming” of the cell.

Exosomes have been shown to be safe due to the fact that no rejection occurs since there are no surface factors, and as they cannot divide, no tumors have been seen to date.