Scientific Article: Key genes associated with NAFLD and AMI

Non-Alcoholic fatty liver (NAFLD) disease is very common type of liver disease all around the world.

Acute Myocardial Infraction (AMI) is one of common causes of death in patients with NAFLD. The

strong association between NAFLD and AMI has been indicated in many previous studies. The

underlying pathophysiology is unknown, but hub genes or pathways related to these diseases can

provide a better knowledge and understanding of correlation between two diseases. The authors of

the given study used bioinformatics methods to find the association of pathways and potential hub

genes for their research. The Gene Expression Omnibus (GEO) database was used for retrieving

datasets for both, NAFLD and AMI patients. Dataset for control subjects was also downloaded from

GEO. Differentially expressed genes for NAFLD and AMI were obtained and further narrowed down

to common genes for both diseases. GO and KEGG was performed. SPSS software was used for

analysing diagnostic values