This report aims to elucidate the current global impact of tuberculosis, shedding light on the persisting challenges faced in both affluent and impoverished regions, with a particular focus on the stark contrasts in disease prevalence. By delving into the intricacies of Mycobacterium tuberculosis, the causative agent of TB, the objective is to provide a comprehensive understanding of its transmission mechanisms and the biological factors contributing to its prevalence in specific populations. The report seeks to highlight the significance of risk factors such as undernourishment, HIV/AIDS, smoking, and chronic conditions in amplifying the impact of tuberculosis, emphasizing the need for targeted interventions to mitigate these factors. With a clear emphasis on the imperative of accurate diagnosis and effective treatment, the report aims to underscore the role of accessible healthcare, diagnostic tools, and antibiotic treatment protocols in reducing the burden of tuberculosis globally, ultimately working towards relegating this ancient disease to history. Investigate the global prevalence and distribution of tuberculosis, examining how the impact varies across regions and elucidating the current status of the disease in both affluent and impoverished nations. Explore the molecular and epidemiological aspects of Mycobacterium tuberculosis, the causative agent of tuberculosis, aiming to provide a comprehensive understanding of its transmission dynamics, virulence factors, and genetic variations. Analyze the influence of key risk factors such as undernourishment, HIV/AIDS, smoking, and pre-existing chronic conditions in exacerbating tuberculosis incidence, emphasizing the need for targeted interventions to address these risk factors. Assess the challenges in diagnosing and treating tuberculosis, with a focus on the importance of early detection, accurate diagnosis, and the implications of undiagnosed cases in fueling antibiotic resistance, ultimately contributing to strategies for improved testing and treatment worldwide.