The term Blockchain has been shaking the finance sector in particular, for a while now. Blockchain technology is frequently being described by words like „disruptive‟, „game changer‟ or „revolution‟. It is also viewed more as a foundational technology with the potential to create new foundations for global economic and social systems, than a disruptive technology. People from all over the world are working hard to find the best solutions concerning the development and testing of vaccines, preventing the spread of infection and quick identification of viral carriers since coronavirus is extremely contagious. In fact, blockchain potential use cases in healthcare vary accordingly to satisfy different requirements, such as data sharing, security, and data access. Other examples include blockchain platforms designed for clinical trials or precision medicine. In the current sense of epidemic management, the blockchain is evolving as a crucial technology solution in providing a transparent, reliable, and low-cost solution to facilitate successful decision-making, which could effectively result in contributing to quicker intervention during this crisis. Blockchain is now showing enough opportunities to become an integral part of fighting against COVID-19 as it would enable efficient tracking and monitoring solutions, ensure a transparent supply chain of vital products and donations, and secure payments. This is possible because blockchain comprises a chronologically ordered list of encrypted signatures, a secure distributed ledger containing permanent transaction records that are shared by all members in the network. Moreover, adopting blockchains and public ledgers maximizes cost savings by eliminating intermediaries that handle manual transactions. The prominent blockchain-based uses cases for combating the COVID-19 pandemic. Blockchain technology is capable of enhancing the healthcare sector in various areas that are affected by this outbreak, including improvements to clinical trials, managing supply chain operations, tracking donations, etc. it effectively responds to the pandemic, and a key territory of opportunity is in the assortment, accumulation, and access to information necessary for the tracking of the infection, deciphering trends, and administering research. Blockchain provides the possibility of guaranteeing data accuracy through its capability to verify and store immutable real-time data. The framework of Block chain acts as a base for new developing research while permitting organizations and associations to share their information with innovators, scientists, and researchers to test and incorporate this information into new devices and solutions. Utilizing a blockchain-fueled platform empowers compliance management, data proprietorship, and auditability to grant flexible sharing through different managerial levels. MiPasa, a worldwide scale control and correspondence system controlled by blockchain innovation, which assists with gathering, collating, and studying data about the virus‟s spread and containment, was launched by WHO while collaborating with significant innovation organizations and governments. MiPasa is an asset that has expectations to help public health officials, the scientific and business network, and people in general. The following benefits could be achieved by using blockchain technology in the healthcare system: