Identifying the symptoms of Nurse burnout is the first step in preventing it from progressing. Nursing burnout is not one size fits all, and there can be many different ways it manifests itself. Nurses can experience various symptoms, including fatigue, sleep problems, headaches, anxiety, loss of desire to go to work, feeling underappreciated, overworked, or unsupported, difficulty with interpersonal relationships, and may even isolate themselves or withdraw from activities.