In 1935, in a Lisbon operating theater, a psychiatrist named António Egas Moniz made medical history—by drilling two holes into a human skull and injecting pure alcohol into the brain’s frontal lobes. His patient: a 63-year-old woman plagued by paralyzing anxiety, delusions, and uncontrollable vomiting. When she awoke, Moniz reported a miracle. Her symptoms had “softened.” She was calm. The first success of a procedure so widely accepted, its inventor won a Nobel Prize, only for history to later condemn it as medical barbarism.