Sometimes it does. Coffee’s health benefits can vary depending on gender and personality differences. Estrogen plays a large role in coffee’s affects on men and women. For example, a
2004 study investigating the relationship between Parkinson’s disease and coffee revealed that postmenopausal women who drink around four cups of coffee a day but also take estrogen replacement therapy are more likely to develop Parkinson’s than men who drink the same amount. A
2011 study reports that when adolescent boys have a high amount of the hormone estradiol in their system, their blood pressure lowers in response to coffee, while high estradiol amounts in adolescent girls increases blood pressure.